Associate Scientist, Stem Cell Biology, Open to flexible working
7 days left
- Contract Type
GlaxoSmithKline is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.
The newly formed Functional Genomics Department at GSK comprises several disciplines that provide the deep scientific knowledge and technical capabilities required to discover and validate potential novel therapeutic targets through the application of extensive genetic analyses, high throughput genome editing and endophenotyping in well-characterised human cellular models.
An exciting opportunity is available for a highly productive and motivated lab-based scientist, with a track record in implementing induced pluripotent stem cell differentiation platforms of human in vitro cellular models. The successful candidate will be based in the Tissue & Cell Sciences group within Functional Genomics at our Medicines Research Centre, Stevenage UK. You will be responsible for culture, differentiation and extensive validation of human iPSC models, using both cellular functional assays and multi-omic approaches. The candidate will be expected to have knowledge and some experience of gene editing technologies for disease modelling and/or screening using human iPSCs. The candidate is also expected to support both small scale iPSC-relevant CRISPR projects to support target validation and large-scale CRISPR screening efforts for target ID. The candidate will have the opportunity to work within a dynamic, highly innovative and multi-disciplined department to support drug discovery projects across multiple therapeutic areas underpinned by immunology.
Key Responsibilities include, but are not limited to:
- Employ and maintain physiological and disease relevant human cell culture systems to support advanced cell-based screening assays (stem cells, primary cells, organoids, 3D cultures).
- Evaluate and implement innovative technologies to enable genome editing procedures in human advanced cell models and apply these to support ongoing target discovery and validation efforts.
- Work in a matrix team environment to enable delivery of project and department objectives to the highest possible scientific standard.
- Ensure compliance with all GSK R&D data integrity practices, ethics codes, standards and training, and safety training and practices.
Closing Date for Applications: 27th September 2020 (COB)
Please take a copy of the Job Description, as this will not be available post closure of the advert.
When applying for this role, please use the 'cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.
During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process. If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements, please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process.
We are looking for professionals with these required skills to achieve our goals:
- Science Degree with demonstrable experience in molecular or cellular biology.
- Experience in advanced mammalian cell culture, including human induced pluripotent stem cells, with good aseptic technique.
- Knowledge of gene editing technologies for cellular disease models.
- Knowledge of molecular biology techniques: PCR, qPCR, NGS, construct design/cloning, CRISPR, shRNA, western blot.
- Experience in developing cellular assays such as ELISA, cell viability, FACS, cell imaging.
- Excellent team-working behaviours, interpersonal and communication skills.
- Strong analytical skills coupled with the ability to problem solve.
- Ability to learn new techniques quickly and accurately.
- Highly committed, enthusiastic, self-motivated with a passion for to learn about the drug discovery process.
If you have the following characteristics, it would be a plus:
- Recent PhD or MSC with equivalent experience.
- Experience in human advanced cell culture, including iPSCs, organoids and other 3D cultures and knowledge of differentiation pathways and phenotypic assays.
- Knowledge of automation or scalable in vitro culture methods.
- Track record of applying cellular functional analysis for target validation and pathway studies.
- Experience in performing genome wide or focused CRISPR screens (arrayed or pooled format).
- Knowledge of multi-omics approaches for target identification and validation.
- Ability to formulate and communicate a coherent research plan.
- Knowledge of pharmacological principles and the ability to interpret the effects of drugs in complex cellular assay systems.
- Strong enterprise behaviour working within multidisciplinary teams.
Our values and expectations are at the heart of everything we do and form an important part of our culture.
These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:
- Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk.
- Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
- Continuously looking for opportunities to learn, build skills and share learning.
- Sustaining energy and well-being.
- Building strong relationships and collaboration, honest and open conversations.
- Budgeting and cost-consciousness.
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We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.
Please don't hesitate to contact us if you'd like to discuss any adjustments to our process which might help you demonstrate your strengths and capabilities.
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