Cell Biologist, Open to flexible working
3 days left
- Contract Type
GlaxoSmithKline is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to support our mission to improve the quality of human life by enabling people to do more, feel better and live longer.
We have an exciting opportunity available for a bright and innovative cell biologist to join GSK's Adaptive Immunity Research Unit in Stevenage. You will be working in a stimulating and fast-moving environment, where we put great emphasis on high quality science. You will join a multidisciplinary team focused on identifying future new medicines that correct dysfunction at the epithelial barrier immune interface. The epithelium of the airway and intestinal tract forms a large mucosal surface that is the first line of defence against pathogens and environmental insults and is an important regulator of the adaptive immune response at mucosal sites. Dysregulated function of the epithelial barrier and altered immune crosstalk results in susceptibility to infections and inflammation which are key recurring features of chronic airway and intestinal diseases. Our role is to identify novel genetically associated targets for barrier diseases through disease phenotyping, integration of genetic and genomic datasets including in collaboration with 23andMe, to validate the targets using disease- and mechanism-relevant in vitro cell and tissue based assays and to progress inhibitors against the targets through lead optimisation and into early clinical development.
As a senior scientist level biologist, you will have the opportunity to contribute to our target identification, validation and lead optimisation efforts. Your initial focus will depend on experience and expertise but could involve contributing to ongoing efforts to establish in vitro cellular and tissue based assay systems that model the airway and intestinal epithelial barrier-immune interface or to applying such assay systems to validation and progression our growing portfolio of novel genetically associated targets.
Key Responsibilities include, but are not limited to:
- As a cell biologist Contributing to the validation, characterisation and progression of novel targets and therapeutics to treat diseases associated with a dysfunctional epithelial barrier/immune interface (primarily intestinal and lung).
- Establishing novel epithelial based cellular assay systems that mirror key aspects of disease for use in target validation and progression.
- Provide in vitro biology support for progression of the departments established research and lead optimisation programs through to clinical candidate selection.
- Collaborating with key academic or clinical alliances (or CROs) who can help further the programs or provide insight into the mechanism of action or therapeutic potential.
- Maintain an active knowledge of external developments in the field and adapting/initiating work plans (internally and externally) in response to emergent data.
- Representing the Research Unit at external meetings and authoring publications in peer-reviewed journals.
- Engagement and sharing expertise with wider AIRU.
Closing Date for Applications: 26th November 2020 (COB)
Please take a copy of the Job Description, as this will not be available post closure of the advert.
When applying for this role, please use the 'cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.
During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process. If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements, please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process.
We are looking for professionals with these required skills to achieve our goals:
- Science graduate with additional research experience ideally in industry or new PhD in Cell Biology, immunology or related discipline.
- Strong understanding of epithelial cell biology and/or immunity gained through research experience.
- Experienced in cell and molecular biological or immunological techniques to characterise cell phenotype and support target validation e.g. gene expression analysis, immunocytochemistry, FACS and immunoassays.
- Comprehensive expertise in experimental design, execution, assay development and analysis.
- Excellent written and verbal communication skills.
If you have the following characteristics, it would be a plus:
- Experienced and proficient in the establishment and functional characterisation of primary human epithelial cell models.
- Experience of early target discovery approaches and disease phenotyping.
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These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:
- Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk.
- Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
- Continuously looking for opportunities to learn, build skills and share learning.
- Sustaining energy and well-being.
- Building strong relationships and collaboration, honest and open conversations.
- Budgeting and cost-consciousness.
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