Senior Scientist - Biochemistry, Open to flexible working

Stevenage, Hertfordshire
19 Nov 2020
24 Nov 2020
Contract Type

GSK is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.

An opportunity has arisen for a highly motivated assay scientist within the department of Screening, Profiling & Mechanistic Biology (SPMB) at GSK's Medicines Research Centre in Stevenage. The department is responsible for broad biological activities predominantly in the pre-clinical drug discovery space, including assay development, compound profiling and mechanism of action studies and comprises of a team of ~ 60 biochemists and cell biologists.

Scientists within the department work in close collaboration with staff from multiple therapeutic areas to define our drug discovery and screening strategies which requires a good foundation of cell biology and biochemistry experience. Hence, the ideal candidate for this position will we have a strong background in these areas to provide target understanding, therapeutic rational and accountability for a broad range of assay development and screening activities across a portfolio of therapeutic targets.

Key Responsibilities include, but are not limited to:

  • Develop biochemical and cellular assays, support screening and determine mechanism of action, across a wide ranging target portfolio.
  • Demonstrate scientific leadership through acting as assay area expert; stay abreast of the latest literature and developments in the field; be accountable for establishing the most suitable in vitro functional assays that enable the selection of potential therapeutics.
  • Contribute to drug discovery project teams as line function lead. Contribute to cross-function project teams by providing leadership in complex biological assay development and the elucidation of MoAs.
  • When suitable, participate in relevant technology projects that optimise/modernise the current drug discovery process.
  • Be able to publish and present both internally and externally.

Closing Date for Applications: Tuesday 24th November 2020

Please take a copy of the Job Description, as this will not be available post closure of the advert.

When applying for this role, please use the 'cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process. If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process.


Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

  • BSc/PhD (or equivalent) in biochemistry, cell biology or other relevant subject area.
  • Knowledge and/or demonstrated experience in the design and development of in vitro biochemical assays utilising multiple fluorescence and label-free technologies.
  • Knowledge and/or demonstrated experience in the design and development of cell-based assays, across multiple cell types and utilising multiple technologies. 
  • Excellent team-working behaviours, interpersonal and communication skills.
  • Strong influencing and analytical skills coupled with the ability to problem solve.
  • Highly committed, enthusiastic, self-motivated and demonstrated passion for learning.

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

  • Broad knowledge of strategies to validate assay relevance to disease.
  • In depth knowledge of at least one therapeutic area and a proven track record of leading and influencing scientific research
  • Knowledge of pharmacological principles and the ability to interpret quantitative data sets from compound profiling experiments.
  • Experience of using laboratory automation for compound screening in an industrial setting, and software solutions for routine and complex data analysis. 
  • Experience with multi-parametric cellular detection systems such as high-content imaging, flow cytometry, high-throughput sandwich immunoassays would be beneficial.
  • Practical experience in the characterisation of isolated targets, which could include compound/inhibitor mechanism studies, catalytic mechanism determination would be beneficial.

Why GSK?

Our values and expectations are at the heart of everything we do and form an important part of our culture.

These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:

  • Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk.
  • Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
  • Continuously looking for opportunities to learn, build skills and share learning.
  • Sustaining energy and well-being.
  • Building strong relationships and collaboration, honest and open conversations.
  • Budgeting and cost-consciousness.

At GSK, we're a company with a special purpose, to help people do more feel better and live longer. Realising our purpose starts with us. When we feel at our best, we perform at our best. When you set out on your adventure at GSK, we make a deal. You commit to living GSK's values and expectations and performing against our Innovation, Performance and Trust priorities. And in return, GSK commits to providing the right environment for you to thrive. Put simply, it's about you being motivated to do your best work, in a place where you can be you, feel good and keep growing. Together we build an environment where we can all thrive and focus on what matters most to each of us. It is only through the energy, dedication, drive and passion of all of us that we can be the very best for GSK, and importantly, for our patients and consumers.

As a company driven by our values of Patient focus, Transparency, Respect and Integrity, we know inclusion and diversity are essential for us to be able to succeed. We want all our colleagues to thrive at GSK bringing their unique experiences, ensuring they feel good and to keep growing their careers. As a candidate for a role, we want you to feel the same way.

As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

Please don't hesitate to contact us if you'd like to discuss any adjustments to our process which might help you demonstrate your strengths and capabilities. 

As you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it. Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially.

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