Senior Scientist - Biochemistry, Open to flexible working
GSK is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.
An opportunity has arisen for a highly motivated assay scientist within the department of Screening, Profiling & Mechanistic Biology (SPMB) at GSK's Medicines Research Centre in Stevenage. The department is responsible for broad biological activities predominantly in the pre-clinical drug discovery space, including assay development, compound profiling and mechanism of action studies and comprises of a team of ~ 60 biochemists and cell biologists.
Scientists within the department work in close collaboration with staff from multiple therapeutic areas to define our drug discovery and screening strategies which requires a good foundation of cell biology and biochemistry experience. Hence, the ideal candidate for this position will we have a strong background in these areas to provide target understanding, therapeutic rational and accountability for a broad range of assay development and screening activities across a portfolio of therapeutic targets.
Key Responsibilities include, but are not limited to:
- Develop biochemical and cellular assays, support screening and determine mechanism of action, across a wide ranging target portfolio.
- Demonstrate scientific leadership through acting as assay area expert; stay abreast of the latest literature and developments in the field; be accountable for establishing the most suitable in vitro functional assays that enable the selection of potential therapeutics.
- Contribute to drug discovery project teams as line function lead. Contribute to cross-function project teams by providing leadership in complex biological assay development and the elucidation of MoAs.
- When suitable, participate in relevant technology projects that optimise/modernise the current drug discovery process.
- Be able to publish and present both internally and externally.
Closing Date for Applications: Tuesday 24th November 2020
Please take a copy of the Job Description, as this will not be available post closure of the advert.
When applying for this role, please use the 'cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.
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We are looking for professionals with these required skills to achieve our goals:
- BSc/PhD (or equivalent) in biochemistry, cell biology or other relevant subject area.
- Knowledge and/or demonstrated experience in the design and development of in vitro biochemical assays utilising multiple fluorescence and label-free technologies.
- Knowledge and/or demonstrated experience in the design and development of cell-based assays, across multiple cell types and utilising multiple technologies.
- Excellent team-working behaviours, interpersonal and communication skills.
- Strong influencing and analytical skills coupled with the ability to problem solve.
- Highly committed, enthusiastic, self-motivated and demonstrated passion for learning.
If you have the following characteristics, it would be a plus:
- Broad knowledge of strategies to validate assay relevance to disease.
- In depth knowledge of at least one therapeutic area and a proven track record of leading and influencing scientific research
- Knowledge of pharmacological principles and the ability to interpret quantitative data sets from compound profiling experiments.
- Experience of using laboratory automation for compound screening in an industrial setting, and software solutions for routine and complex data analysis.
- Experience with multi-parametric cellular detection systems such as high-content imaging, flow cytometry, high-throughput sandwich immunoassays would be beneficial.
- Practical experience in the characterisation of isolated targets, which could include compound/inhibitor mechanism studies, catalytic mechanism determination would be beneficial.
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These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:
- Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk.
- Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
- Continuously looking for opportunities to learn, build skills and share learning.
- Sustaining energy and well-being.
- Building strong relationships and collaboration, honest and open conversations.
- Budgeting and cost-consciousness.
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