Senior Scientist- Molecular and Cellular Biology, Open to flexible working
4 days left
- Contract Type
The Novel Human Genetics research unit at GSK comprises a multidisciplinary team that utilises deep scientific knowledge and technical capabilities to identify and validate novel therapeutic targets and undertake drug discovery from early stage discovery through to phase 1 clinical trials.
Two exciting opportunities are available for talented, highly-motivated scientists to fill molecular and cellular biologist positions within the Novel Human Genetics Research Unit, Stevenage. You will be responsible for the conceptual design and lab-based execution of in vitro experiments for target identification and validation, quantitative pharmacology experiments and mechanism of action studies to support pipeline projects. You will be responsible for integrating analyses and interpreting the output of these studies. You will work on projects across multiple therapeutic areas, including neuroscience and immune / autoinflammatory disease. You will be a go-to person for practical cell biology expertise, including primary cells / iPSCs and image analytics.
You will focus on designing and executing key decision-making studies in a timely and efficient manner, whilst maintaining the highest scientific standards and compliance. You will need strong hands-on experience in multiple cellular assay systems, in gene engineering and iPSC differentiation. In order to execute target validation and early drug discovery successfully you will be required to work independently and as part of a team. You will be a strong team player and a good communicator. This role would suit a candidate with the aspiration to make critical lab-based contributions to early drug discovery and target validation.
- Design and implementation of novel physiological and disease-relevant human cell culture systems to support target validation and assay development for drug discovery. Including one or more of the following;
- Imaging assay development including automated image analysis using ML tools (python programming skills desirable).
- Differentiation of iPSCs to understand the impact of genetic variants on disease phenotypes, experience in sensory neurons would be of particular benefit here.
- Modulation of gene expression via RNAi and CRISPR in disease-relevant cellular systems to understand biological and drug mechanism of action.
- Understanding mechanism of action using quantitative pharmacology/ electrophysiology.
- Become a core part of the team with excellent communication skills. Work in a matrix team environment to enable delivery of project and department objectives to the highest possible scientific standards.
- Ensure compliance with all GSK R&D data integrity practices, ethics codes, standards and training, and safety.
When applying for one of these roles, please use the 'cover letter' of the on-line application to describe how you meet the competencies for this role, as outlined in the job requirements above.
The information that you have provided in your cover letter and CV will be used to assess your application.
- PhD and postdoc, or equivalent experience, in in vitro cellular experiments.
- Demonstrated expertise across a broad range of cellular assay systems, including primary cells and engineered cell lines.
- Experience in a broad range of molecular and cellular biology techniques including cell culture and one or more of the following:
- Hands-on experience with High Content Screening imaging platforms and developing automated workflows.
- Experience in human iPSC culture and knowledge of differentiation pathways and phenotypic assays.
- Experience in Flow cytometry, RNAi or CRISPR.
- Molecular Pharmacology and Electrophysiology.
- Excellent attention to detail in method development and data analysis. Strong analytical skills coupled with the ability to problem solve.
- Strong behaviours for working within multidisciplinary teams. Excellent team-working, interpersonal and communication skills.
- Highly committed, enthusiastic, self-motivated with a passion for learning and a strong focus on personal development.
- Track record of applying cellular functional analysis for target identification, validation and pathway studies.
- Knowledge of pharmacological principles and the ability to interpret the effects of drugs in complex cellular assay systems.
- Demonstrated experience in effective communications and presentations in a matrix team environment.
- Demonstrated knowledge of drug discovery.
Our values and expectations are at the heart of everything we do and form an important part of our culture.
These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:
- Agile and distributed decision-making - using evidence and applying judgement to balance pace, rigor and risk
- Managing individual and team performance.
- Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
- Implementing change initiatives and leading change.
- Sustaining energy and well-being, building resilience in teams.
- Continuously looking for opportunities to learn, build skills and share learning both internally and externally.
- Developing people and building a talent pipeline.
- Translating strategy into action - a compelling narrative, motivating others, setting objectives and delegation.
- Building strong relationships and collaboration, managing trusted stakeholder relationships internally and externally.
- Budgeting and forecasting, commercial and financial acumen.
As a company driven by our values of Patient focus, Transparency, Respect and Integrity, we know inclusion and diversity are essential for us to be able to succeed. We want all our colleagues to thrive at GSK bringing their unique experiences, ensuring they feel good and to keep growing their careers. As a candidate for a role, we want you to feel the same way.
As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).
We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.
Please don't hesitate to contact us if you'd like to discuss any adjustments to our process which might help you demonstrate your strengths and capabilities.
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