Flow Cytometry Scientist, Open to flexible working

Location
Stevenage, Hertfordshire
Salary
£Competitive
Posted
17 Mar 2021
Closes
11 Apr 2021
Ref
283056
Contract Type
Permanent

We are looking for a highly motivated, flexible and experienced scientist to join the Cellular Biomarkers Flow Cytometry team within the Bioanalysis, Immunogenicity and Biomarkers (BIB) department based in Stevenage, UK. The group is responsible for the development and validation of complex multi-parameter flow cytometry panels as well as application of these panels to clinical trial sample analysis. The deep immunophenotyping data generated by these biomarker panels helps us to evaluate disease heterogeneity, drug-target engagement, drug mechanism of action and patient responses.

The successful candidate will have a deep understanding of immunology and will act as a flow cytometry technical expert, supporting high parameter deep immunophenotyping of immune cell subsets as well as receptor occupancy endpoints. This role will include all aspects of flow cytometry method development and optimisation, validation and sample analysis for clinical studies across the entire GSK portfolio. This role will be responsible for completion of all aspects of assay workflow including reagent selection, sample preparation, sample acquisition, data analysis, interpretation, and presentation. In addition, this role will ensure all work is conducted in compliance with GLP/GCP regulations (when necessary) and follow the appropriate SOPs.

Key Responsibilities: 

  • Generate high quality data to support clinical studies by spectral flow cytometry (Cytek Aurora)
  • Conduct and oversee all aspects of method development, troubleshooting, validation and sample analysis for clinical studies
  • Handling of human biological samples and performing experimental work in accordance with GLP/GCP, safety and data integrity guidelines
  • Be responsible for delivery of robust, high quality data packages
  • Deliver, interpret and communicate complex scientific data to project/program teams within agreed timelines
  • Ability to handle multiple projects concurrently
  • Able to function well in a team and possess a good balance of creative and analytical skills
  • Contribute to biomarker strategy and capital equipment discussions
  • Help lead efforts to investigate novel cytometry and data analysis platforms and embed within the organization
  • Willingness to develop and train others as required

Basic Qualifications:

This role requires a PhD in Immunology or a related field with a post-PhD experience or a bachelor with extensive post-graduation experience in immunology, cell biology, biomedical science or related disciplines. In addition:

  • Strong immunological knowledge enabling phenotyping of multiple subpopulations of cells
  • Strong theoretical and practical understanding of flow cytometry with experience to design and execute 12+ color flow cytometry panels
  • Strong laboratory experience and expertise working with a variety of sample types including whole blood, PBMC, cell lines and single-cell suspension from tissue samples
  • Considerable experience in the use of flow cytometry analysis software (FlowJo and FCS Express preferred)
  • Ability to maintain a disciplined approach, ensuring a relentless focus on quality, compliance, scientific rigor and operational excellence
  • Attention to detail, good communication and documentation skills
  • Ability to work independently to tight deadlines with a proactive attitiude
  • Be a highly motivated team player with the ability to interact effectively within a multi-disciplinary team
  • Ability to problem solve and troubleshoot
  • Demonstrated judgment and decision making, especially for prioritizing multiple requests
  • A good understanding of the drug development process

Preferred Qualifications:

  • Experience to design and execute 18+ color flow cytometry panels
  • Hands on practical experience with the Cytek Aurora
  • Strong laboratory experience and understanding of clinical and non-clinical flow cytometry biomarker assay development, validation and implementation
  • Hands on experience with high-dimensional data analysis ( e.g. tSNE, SPADE, CITRUS, FlowSOM) 
  • Experience of technology transfer of flow cytometry assays to Contract Research Organisations
  • Hands on experience with OMIQ software
  • Experience of writing SOPs and other regulated documents

As a company driven by our values of Patient focus, Transparency, Respect and Integrity, we know inclusion and diversity are essential for us to be able to succeed. We want all our colleagues to thrive at GSK bringing their unique experiences, ensuring they feel good and to keep growing their careers. As a candidate for a role, we want you to feel the same way.

As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

As you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it. Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially.

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