Cell Line Selection Scientist, Open to flexible working

3 days left

Stevenage, Hertfordshire
01 Apr 2021
20 Apr 2021
Contract Type

GlaxoSmithKline (GSK) is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.

We are seeking an autonomous and inventive individual to integrate into an established team of research scientists in GSK's Biopharmaceutical Process Research Department (BPR). Positioned at a pivotal interface between Discovery and CMC, this department is tasked with accelerating the progression of a portfolio of novel biopharmaceuticals to the clinic. To achieve this, BPR brings together scientists across a number of disciplines to deliver our core project remit whilst positioning ourselves at the forefront of cutting-edge technologies.

Recent investment in automated cell line development and upstream platforms, combined with cutting edge analytical techniques and advanced data analysis is enabling us to better understand our cell lines and platform processes and increase our metabolic and biochemical knowledge of our cell lines. We are now looking to leverage and increase these enhanced datasets by expanding our cell line selection team to link cell biology and performance to cell line development data to drive commercialisable cell line selection earlier in the process.

The role will involve generating comprehensive data sets to drive final cell line selection using automated microbioreactor systems and their associated analytics. As we identify additional predictive markers of cell line performance the successful applicant will be tasked with establishing these analyses in our ambr15 workflows and generating the appropriate data to augment our cell line selection data package. Key to this success will be an innovative mindset coupled with the ability to drive complex multidisciplinary studies within project campaigns to better inform cell selection decisions.

Leading from the lab the successful candidate will be confident in generating CHO cell performance and biochemical data and linking this to cell line performance criteria by working closely with our Cell Line Development, Data Science and OneStream groups to support our Next Generation Cell Line Development capability.

Key Responsibilities include, but are not limited to:

  • Using our production process models, deliver project critical data packages to inform cell line selection decisions.
  • Identify and evaluate opportunities to generate enhanced datasets from our current CLD/cell selection processes.
  • Through focussed experimental work and continuous improvement proactively embed novel analytics into our standard workflows and actively seek opportunities to enhance the quality and depth of our cell screening processes.
  • Contribute to wider automation, data analysis and bioinformatic work packages within BPR to support our Next Generation Cell Line Development capability.
  • Be an active and adaptable member of an established and highly effective BPD team, willing to support and priorities wider team deliverables when portfolio demands require.
  • Possesses excellent planning and communication skills to interact effectively within a multi-disciplinary team and with other internal and external business partners using influencing, communication and relationship building skills.
  • Demonstrated ability to effectively communicate your work and data to various audiences in the form of presentations and written reports.

Closing Date for Applications: Tuesday 20th April 2021

Please take a copy of the Job Description, as this will not be available post closure of the advert.

When applying for this role, please use the 'cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process. If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements, please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process.

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

  • PhD, MSc or equivalent experience in Mammalian Cell Biology, Biochemistry or a related field
  • Practical experience of mammalian cell culture/CHO cell biology at bench and/or bioreactor scale
  • Track record of design, execution and analysis of work packages to improve CHO cell selection through data driven cross-scale modelling
  • Ability to proactively contribute to team performance and process improvement in a climate of scientific rigor across multiple CHO process science groups
  • Effective communication skills

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

  • Experience of using multivariate data analysis and 'omic data outputs to enhance experimental outcomes
  • Knowledge of, and ability to apply, experimental design and data analysis principles to derive quality results in a timely fashion
  • Proven experience of evaluation and implementation of appropriate new ideas and technologies
  • Ability to apply innovative solutions to process development problems
  • Understanding of cell line selection in an industrial setting and the ability to proactively contribute to data driven continuous process improvement

Why GSK?

Our values and expectations are at the heart of everything we do and form an important part of our culture.

These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:

  • Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk.
  • Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
  • Continuously looking for opportunities to learn, build skills and share learning.
  • Sustaining energy and well-being.
  • Building strong relationships and collaboration, honest and open conversations.
  • Budgeting and cost-consciousness.

At GSK, we're a company with a special purpose, to help people do more feel better and live longer. Realising our purpose starts with us. When we feel at our best, we perform at our best. When you set out on your adventure at GSK, we make a deal. You commit to living GSK's values and expectations and performing against our Innovation, Performance and Trust priorities. And in return, GSK commits to providing the right environment for you to thrive. Put simply, it's about you being motivated to do your best work, in a place where you can be you, feel good and keep growing. Together we build an environment where we can all thrive and focus on what matters most to each of us. It is only through the energy, dedication, drive and passion of all of us that we can be the very best for GSK, and importantly, for our patients and consumers.

As a company driven by our values of Patient focus, Transparency, Respect and Integrity, we know inclusion and diversity are essential for us to be able to succeed. We want all our colleagues to thrive at GSK bringing their unique experiences, ensuring they feel good and to keep growing their careers. As a candidate for a role, we want you to feel the same way.

As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

As you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it. Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially.

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