CHO Cell Biologist, Open to flexible working
7 days left
- Contract Type
GlaxoSmithKline (GSK) is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.
We are seeking an autonomous and inventive individual to integrate into an established team of research scientists in GSK's Biopharmaceutical Process Research Department (BPR). Positioned at a pivotal interface between Discovery and CMC, this department is tasked with accelerating the progression of a portfolio of novel biopharmaceuticals to the clinic. To achieve this, BPR brings together scientists across a number of disciplines to deliver our core project remit whilst positioning ourselves at the forefront of cutting-edge technologies.
Recent investment in automated cell line development and upstream platforms, combined with cutting edge analytical techniques and advanced data analysis is enabling us to better understand our cell lines and platform processes and increase the metabolic and biochemical knowledge of our cell lines. We are now looking to leverage and expand these enhanced datasets by linking cell biology and performance to cell line development data to drive the selection of commercialisable cell lines earlier in the process.
The role will primarily involve investigating the phenotypic characteristics of our CHO-based mammalian expression platform cell lines in scale down models of our production processes and applying these findings to deliver an in-depth understanding of the biological mechanisms dictating cell line behaviours. Using their knowledge of mammalian cell biology and recent advances in 'omic technologies, preferably coupled with hands-on experience in intracellular biochemistry, signalling, and/or protein trafficking, the successful applicant would be tasked with seeking and applying novel analytical approaches to systematically decipher the key mediators influencing cellular phenotypes.
We expect the outcomes of this work to generate a better understanding of our platform cell lines and the associated residuals (host cell proteins), resulting in more deeply informed cell line selection decisions during project campaigns. We also envisage this will enable us to exert greater control over the performance of our cell lines during process development and may identify targets for host cell engineering.
The successful candidate must be confident in seeking, critically evaluating and where appropriate, embedding, innovative technologies into our cell line selection workflows. Leading from the lab they will link biochemical and 'omic data to cell line performance criteria by working closely with our Cell Line Development, Data Science and OneStream groups to support our Next Generation Cell Line Development capability.
Key Responsibilities include, but are not limited to:
- Use advanced data analysis and model building to identify cellular characteristics that may be predictive of cell lines with desirable processing attributes. Investigate and strive to understand the underlying biology related to these characteristics and determine methods to exploit and apply these characteristic differences in our cell line selection workflows.
- Actively seek and evaluate novel technologies (which may exist both within GSK and externally) that could advance this area of work or align with other strategies in the departmental business plan.
- Use cross-scale metabolic, biochemical and spectral data to build process independent models for cell line selection by working with our CLD and Data groups to enhance our understanding of metabolic and biochemical factors influencing cell line performance.
- Deliver our holistic cell line selection vision by proposing and undertaking focused experimental work packages to build and validate molecule/process agnostic models for cell line selection.
- Contribute to wider automation, data analysis and bioinformatic work packages within BPR to support our Next Generation Cell Line Development capability.
- Be an active and adaptable member of an established and highly effective BPD team, willing to support and priorities wider team deliverables when portfolio demands require.
- Possesses excellent planning and communication skills to interact effectively within a multi-disciplinary team and with other internal and external business partners using influencing, communication and relationship building skills.
- Demonstrated ability to effectively communicate your work and data to various audiences in the form of presentations and written reports.
- Seek all opportunities to develop and maintain a strong IP position.
Closing Date for Applications: Tuesday 20th April 2021
Please take a copy of the Job Description, as this will not be available post closure of the advert.
When applying for this role, please use the 'cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.
During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process. If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements, please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process.
We are looking for professionals with these required skills to achieve our goals:
- PhD in Mammalian Cell Biology, Biochemistry or a related field
- Extensive practical experience of mammalian cell culture/CHO cell biology at bench and/or bioreactor scale
- Track record of design, execution and analysis of work packages to improve CHO cell selection through data driven cross-scale modelling
- Ability to proactively contribute to team performance and process improvement in a climate of scientific rigor across multiple CHO process science groups
- Effective communication skills
If you have the following characteristics, it would be a plus:
- Experience of using multivariate data analysis and 'omic data outputs to enhance experimental outcomes
- Knowledge of, and ability to apply, experimental design and data analysis principles to derive quality results in a timely fashion
- Proven experience of evaluation and implementation of appropriate new ideas and technologies
- Ability to apply innovative solutions to process development problems
- Understanding of cell line selection in an industrial setting and the ability to proactively contribute to data driven continuous process improvement
Our values and expectations are at the heart of everything we do and form an important part of our culture.
These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:
- Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk.
- Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
- Continuously looking for opportunities to learn, build skills and share learning.
- Sustaining energy and well-being.
- Building strong relationships and collaboration, honest and open conversations.
- Budgeting and cost-consciousness.
At GSK, we're a company with a special purpose, to help people do more feel better and live longer. Realising our purpose starts with us. When we feel at our best, we perform at our best. When you set out on your adventure at GSK, we make a deal. You commit to living GSK's values and expectations and performing against our Innovation, Performance and Trust priorities. And in return, GSK commits to providing the right environment for you to thrive. Put simply, it's about you being motivated to do your best work, in a place where you can be you, feel good and keep growing. Together we build an environment where we can all thrive and focus on what matters most to each of us. It is only through the energy, dedication, drive and passion of all of us that we can be the very best for GSK, and importantly, for our patients and consumers.
As a company driven by our values of Patient focus, Transparency, Respect and Integrity, we know inclusion and diversity are essential for us to be able to succeed. We want all our colleagues to thrive at GSK bringing their unique experiences, ensuring they feel good and to keep growing their careers. As a candidate for a role, we want you to feel the same way.
As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).
We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.
As you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it. Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially.
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