Investigator, Single Cell CRISPR Screening, Open to flexible working

Location
Stevenage, Hertfordshire
Salary
£Competitive
Posted
23 Apr 2021
Closes
06 May 2021
Ref
287550
Contract Type
Permanent

GlaxoSmithKline is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.

We are seeking a highly motivated, enthusiastic and skilled biologist to join our Genome Biology (GB) group within the Functional Genomics (FxG) department at our UK Research Site. The mission of our group is to unlock the genetic clues underlying human disease, thereby delivering new and better medicines for individuals with serious and greatest unmet medical need. To this end, we leverage the power of CRISPR and other gene editing technologies in high-throughput screening approaches, applied to in vitro and in vivo preclinical models, for the discovery and validation of novel disease targets or genetic variants, understanding mechanisms of drug action and resistance, and identifying potential combination therapies. Together with the ability to draw on genotypic and phenotypic databases from our world-leading partnerships with the UK BioBank and 23andMe, and to interrogate the genome through internal and collaborative efforts with the Altius Institute, Open Targets, and the Laboratory of Genomics Research (LGR), we aim to redefine how the industry approaches drug discovery.

The successful candidate will be part of the single cell CRISPR group exploring and applying advanced genome editing approaches coupled with single cell technologies for target discovery, disease model validation and biomarker discovery. We are looking for a scientist with extensive experience in pooled CRISPR screening, ideally with a single cell transcriptome readout.

Key Responsibilities include, but are not limited to:

  • Your primary focus will be in the laboratory, with a deep desire to drive drug discovery projects. You will be expected to design and implement CRISPR screening experiments and coordinate/enable/assist data analysis.
  • You will demonstrate the ability to work effectively in multidisciplinary teams and will display excellent interpersonal and communication skills, interacting with scientists and external collaborators at all levels.
  • You will be expected to maintain knowledge of current scientific literature relevant to the role.
  • A proactive attitude, excellent organisational skills and good record keeping are essential. You will be expected to present your results/data at both internal and external meetings.
  • Ensure compliance with all GSK R&D data integrity practices, ethics codes, standards and training, and safety training and practices.

Closing Date for Applications: Thursday 6th May'21

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

  • PhD or equivalent experience in molecular and cellular biology, genomics or a related discipline.
  • Demonstrated experience in designing and implementing focused or genome-wide pooled CRISPR screens, employing physiological- and/or disease-relevant cellular models and assays. Good understanding of CRISPR screen design, the various CRISPR perturbation approaches and their limitations.
  • Experience (or an excellent understanding) in CRISPR screening with scRNAseq readout (e.g. CROPseq, Perturb-Seq).
  • Great understanding of single cell transcriptomics and related technologies.
  • Sound knowledge of molecular biology techniques including: flow cytometry, qRT-PCR, molecular cloning, etc.
  • Demonstrated ability to design experiments, solve problems independently, troubleshoot protocols and implement omics studies/protocols.
  • Proven ability to work independently and as part of a multidisciplinary team
  • Strong organisational and communication skills and a demonstrated ability to liaise with scientists and external collaborators at all levels of seniority.
  • Ability to generate scientific reports and present data to senior stakeholders.

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

  • Demonstrated experience in working with complex in vitro models, such as primary (immune) cells, iPSCs or organoids/spheroids.
  • Good understanding of genetics and epigenetics.
  • Good understanding of immunology.
  • Experience in dual gene CRISPR perturbation screens.
  • Experience or good understanding of single cell analysis methodologies.

Why GSK?

Our values and expectations are at the heart of everything we do and form an important part of our culture.

These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:

  • Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk.
  • Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
  • Continuously looking for opportunities to learn, build skills and share learning.
  • Sustaining energy and well-being.
  • Building strong relationships and collaboration, honest and open conversations.
  • Budgeting and cost-consciousness.

Please take a copy of the Job Description, as this will not be available post closure of the advert.

When applying for this role, please use the 'cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process. If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process.

As a company driven by our values of Patient focus, Transparency, Respect and Integrity, we know inclusion and diversity are essential for us to be able to succeed. We want all our colleagues to thrive at GSK bringing their unique experiences, ensuring they feel good and to keep growing their careers. As a candidate for a role, we want you to feel the same way.

As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

As you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it. Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially.

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