PKPD modeler, Open to flexible working
GSK is seeking a highly motivated and experienced mechanistic modeling scientist to join our Drug Metabolism and Pharmacokinetics modeling team. This team impacts candidate drug selection and the early clinical development strategy. The successful applicant will be a scientific leader, developing and driving the preclinical PK/PD strategy for projects with the aim to deliver a robust prediction of the human efficacious dose.
Key Responsibilities include:
- Develop and execute a modelling-based strategy for preclinical projects and lead the project team discussions on the human dose prediction prior to candidate selection.
- Use PKPD modeling to generate hypotheses and design better, model-informed experiments.
- Develop and apply PKPD models to influence critical decisions in drug discovery and development, including target selection, lead optimisation, candidate selection and early clinical development.
- Establish concentration-effect relationships, linking drug, target PD and efficacy, from preclinical experiments and provide translation modeling to predict human effects, human doses and early design of clinical trials.
- Work closely with other preclinical scientists and with matrix teams to aid the design of experiments and interpretation of the data generated to define project direction and decisions.
- Communicate/ report modelling predictions to key stakeholders to facilitate strategy and decision-making
- Active engagement with external modeling community and maintain awareness of new /emerging techniques relevant to the field.
- Manage student and post doc programmes
We are looking for professionals with these required skills to achieve our goals:
- MS or PhD in relevant scientific discipline (e.g. Pharmacology, pharmaceutical sciences or related fields such as maths, physics and engineering)
- 5 years' experience in providing PK/PD input into the design and interpretation of early preclinical in vivo studies
- 3 years' experience of ADME and pharmacokinetics, (non-compartmental, compartmental, PBPK) and the use of pre-clinical data for human efficacious dose prediction.
- 3 years' experience in the use of software and applications in the area of PKPD modeling and simulation (e.g. NONMEM, R, Phoenix, MATLAB, Berkeley Madonna or comparable tools)
If you have the following characteristics, it would be a plus:
- A successful track record of applying translational PK/PD modelling.
- The ability to work independently, excellent interpersonal, organizational, oral/written communication and teamwork skills
- Able to prioritise and work as part of a cross-functional team
- Active contributions to external consortia; presenting at conferences and contribution to scientific publications.
Our values and expectations are at the heart of everything we do and form an important part of our culture.
These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:
- Agile and distributed decision-making - using evidence and applying judgement to balance pace, rigour and risk
- Managing individual and team performance.
- Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
- Implementing change initiatives and leading change.
- Sustaining energy and well-being, building resilience in teams.
- Continuously looking for opportunities to learn, build skills and share learning both internally and externally.
- Developing people and building a talent pipeline.
- Translating strategy into action - a compelling narrative, motivating others, setting objectives and delegation.
- Building strong relationships and collaboration, managing trusted stakeholder relationships internally and externally.
- Budgeting and forecasting, commercial and financial acumen.
As a company driven by our values of Patient focus, Transparency, Respect and Integrity, we know inclusion and diversity are essential for us to be able to succeed. We want all our colleagues to thrive at GSK bringing their unique experiences, ensuring they feel good and to keep growing their careers. As a candidate for a role, we want you to feel the same way.
As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).
We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.
As you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it. Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially.
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