Electrophysiologist, Open to flexible working
The Novel Human Genetics research unit at GSK comprises a multidisciplinary team that utilises deep scientific knowledge and technical capabilities to identify and validate novel therapeutic targets and undertake drug discovery from early stage discovery through to phase 1 clinical trials.
An exciting opportunity is available for a talented, highly-motivated electrophysiologist within Novel Human Genetics Research Unit, Stevenage. You will be responsible for the conceptual design and lab-based execution of in vitro and ex vivo experiments for target identification and validation, quantitative pharmacology experiments and mechanism of action studies to support pipeline projects. You will be responsible for integrating analyses and interpreting the output of these studies. You will work on projects across multiple therapeutic areas, including neuroscience and pain. You will be a go-to person for practical electrophysiology expertise.
You will focus on designing and executing key decision-making studies in a timely and efficient manner, whilst maintaining the highest scientific standards and compliance. You will need strong hands-on experience in patch clamp electrophysiology. In order to execute target validation and early drug discovery successfully you will be required to work independently and as part of a team. You will be a strong team player and a good communicator. This role would suit a candidate with the aspiration to make critical lab-based contributions to early drug discovery.
- Pharmacological characterisation of ion channels, including SNPs associated with disease.
- Design and execution of manual patch clamp experiments in iPSC lines and isolated neurons.
- Design and implementation of microelectrode array (MEA) and calcium imaging experiments.
- Become a core part of the team with excellent communication skills. Work in a matrix team environment to enable delivery of project and department objectives to the highest possible scientific standards.
- Ensure compliance with all GSK R&D data integrity practices, ethics codes, standards and training, and safety.
When applying for this role, please use the 'cover letter' of the on-line application to describe how you meet the competencies for this role, as outlined in the job requirements above.
The information that you have provided in your cover letter and CV will be used to assess your application.
During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process.
If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements, please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process.
We are looking for professionals with these required skills to achieve our goals:
- PhD and postdoc, or equivalent experience, in in vitro electrophysiology.
- Demonstrable knowledge of ion channel biophysics and pharmacology.
- Hands on technical expertise in developing ion channel assays (manual and automated).
- Experience in translational assays, including native tissue preparation and recording would be advantageous.
- Excellent attention to detail in method development and data analysis. Strong analytical skills coupled with the ability to problem solve.
- Strong behaviours for working within multidisciplinary teams. Excellent team-working, interpersonal and communication skills.
- Highly committed, enthusiastic, self-motivated with a passion for learning and a strong focus on personal development.
If you have the following characteristics, it would be a plus:
- Track record of applying cellular functional analysis for target identification, validation and pathway studies.
- Knowledge of pharmacological principles and the ability to interpret the effects of drugs in complex cellular assay systems.
- Demonstrated experience in effective communications and presentations in matrix team environment.
- Demonstrated knowledge of drug discovery
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