Electrophysiologist, Open to flexible working

Location
Stevenage, Hertfordshire
Salary
£Competitive
Posted
26 May 2021
Closes
20 Jun 2021
Ref
290783
Contract Type
Permanent

The Novel Human Genetics research unit at GSK comprises a multidisciplinary team that utilises deep scientific knowledge and technical capabilities to identify and validate novel therapeutic targets and undertake drug discovery from early stage discovery through to phase 1 clinical trials.

An exciting opportunity is available for a talented, highly-motivated electrophysiologist within Novel Human Genetics Research Unit, Stevenage. You will be responsible for the conceptual design and lab-based execution of in vitro and ex vivo experiments for target identification and validation, quantitative pharmacology experiments and mechanism of action studies to support pipeline projects. You will be responsible for integrating analyses and interpreting the output of these studies. You will work on projects across multiple therapeutic areas, including neuroscience and pain. You will be a go-to person for practical electrophysiology expertise.

You will focus on designing and executing key decision-making studies in a timely and efficient manner, whilst maintaining the highest scientific standards and compliance. You will need strong hands-on experience in patch clamp electrophysiology. In order to execute target validation and early drug discovery successfully you will be required to work independently and as part of a team. You will be a strong team player and a good communicator. This role would suit a candidate with the aspiration to make critical lab-based contributions to early drug discovery.

Key Responsibilities:

  • Pharmacological characterisation of ion channels, including SNPs associated with disease.
  • Design and execution of manual patch clamp experiments in iPSC lines and isolated neurons.
  • Design and implementation of microelectrode array (MEA) and calcium imaging experiments.
  • Become a core part of the team with excellent communication skills. Work in a matrix team environment to enable delivery of project and department objectives to the highest possible scientific standards.
  • Ensure compliance with all GSK R&D data integrity practices, ethics codes, standards and training, and safety.

When applying for this role, please use the 'cover letter' of the on-line application to describe how you meet the competencies for this role, as outlined in the job requirements above.

The information that you have provided in your cover letter and CV will be used to assess your application.

During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process.

If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements, please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process.

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

  • PhD and postdoc, or equivalent experience, in in vitro electrophysiology.
  • Demonstrable knowledge of ion channel biophysics and pharmacology.
  • Hands on technical expertise in developing ion channel assays (manual and automated).
  • Experience in translational assays, including native tissue preparation and recording would be advantageous.
  • Excellent attention to detail in method development and data analysis. Strong analytical skills coupled with the ability to problem solve.
  • Strong behaviours for working within multidisciplinary teams. Excellent team-working, interpersonal and communication skills.
  • Highly committed, enthusiastic, self-motivated with a passion for learning and a strong focus on personal development.

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

  • Track record of applying cellular functional analysis for target identification, validation and pathway studies.
  • Knowledge of pharmacological principles and the ability to interpret the effects of drugs in complex cellular assay systems.
  • Demonstrated experience in effective communications and presentations in matrix team environment.
  • Demonstrated knowledge of drug discovery

Why GSK?

At GSK, we're a company with a special purpose, to help people do more feel better and live longer. Realising our purpose starts with us. When we feel at our best, we perform at our best.

When you set out on your adventure at GSK, we make a deal. You commit to living GSK's values and expectations and performing against our Innovation, Performance and Trust priorities. And in return, GSK commits to providing the right environment for you to thrive. Put simply, it's about you being motivated to do your best work, in a place where you can be you, feel good and keep growing.

Together we build an environment where we can all thrive and focus on what matters most to each of us. It is only through the energy, dedication, drive and passion of all of us that we can be the very best for GSK, and importantly, for our patients and consumers.

As a company driven by our values of Patient focus, Transparency, Respect and Integrity, we know inclusion and diversity are essential for us to be able to succeed. We want all our colleagues to thrive at GSK bringing their unique experiences, ensuring they feel good and to keep growing their careers. As a candidate for a role, we want you to feel the same way.

As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

As you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it. Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially.

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