Chemical Biologist, Open to flexible working
5 days left
- Contract Type
- Contract - interim/fixed term
1 Year Fixed Term Contract: Chemical Biology (UK) Team, Medicines Design, MST
Building on GSK's strategic investment in human genetic and functional genomics, a dedicated Chemical Biology team was recently established to support the delivery of our early stage pipeline of innovative medicines. Working in partnership with our Research Units, and Medicines Design organisation, our team of chemical biologists sets out to identify small molecule probes to support target identification and validation as well as assessing target tractability and informing modality selection.
An opportunity has now arisen for a chemical biologist to join the department on a fixed term basis.
Roles and Responsibilities
The role is for a laboratory-based scientist carrying out experimental work directly in support of GSK's expanding early stage discovery pipeline. The successful candidate will be fully integrated into the team and will be expected to contribute to a culture and environment of scientific excellence. The role will be highly collaborative and provide opportunity to develop insight into early stage drug discovery along with the flexibility to broaden laboratory skills at the interface between medicinal chemistry and protein sciences/screening. A key element of practical work will include involvement the laboratory's LCMS screening platform for reactive fragments.
- Maintain high productivity in practical chemical biology.
- Contribute to the design and implementation of experiments to address biological questions.
- Interpret and communicate complex scientific data.
- Integrate effectively into the chemical biology department.
Key capabilities and desired experience
- A track record of high personal productivity working across the chemistry/biology interface, including excellent synthetic chemistry skills. Some experience of mass spectrometry and hands-on practical experience using biochemical assays and proteomic workflows would be advantageous, though not an essential requirement.
- Knowledge of contemporary chemical biology techniques in relation to small molecule drug discovery is highly desirable, particularly with respect to target identification, validation, tractability and engagement.
- Self-starting, proactive working style with an ability to work flexibly and manage multiple tasks simultaneously.
- Experience of effective collaborative working in an integrated scientific setting, for example with biochemists, chemoproteomics scientists and cell biologists.
- Ability to critically analyse, assimilate, and communicate complex scientific data.
- Commitment to personal professional development.
This position is expected to appeal to medicinal chemists or chemical biologists that have a profound interest in the practical application of chemistry to the solution of biological problems. The successful applicant can expect excellent onward training in chemical biology as well as the opportunity to collaborate with experts working in other disciplines; particularly molecular biology, high throughput chemistry and medicinal chemistry.
Please use your covering letter to highlight how you fit the applicant profile and meet the skills and competencies for the role. Your covering letter, along with your CV, will be used to assess your application.
We are looking for professionals with these required skills to achieve our goals:
- PhD/DPhil (or about to be awarded a PhD) in organic chemistry, medicinal chemistry, bioorganic chemistry or chemical biology OR
- Strong industrial experience in this field
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