Senior Scientist- Biopharm Cell Line Development, Open to flexible working

Expiring today

Stevenage, Hertfordshire
05 Oct 2021
24 Oct 2021
Contract Type

The Biopharm Cell Line Development (CLD) group is seeking to expand its team of enthusiastic and passionate scientists, dedicated to driving the progression of GSK’s Biopharm portfolio by the delivery of high-quality, commercialisable cell lines expressing Biopharmaceutical molecules.

Cell Line Development sits within the wider Biopharm Process Research (BPR) group whose key remit is to accelerate the development of Biopharmaceutical assets into clinical manufacture by linking drug discovery and product development. By the application of techniques varying from traditional molecular biology and cell culture through to bespoke automation programming, cellular analysis and data visualisation; CLD scientists facilitate the development of thousands of cell lines per year in support of multiple projects running concurrently. CLD scientists work together with their process development and analytical colleagues in triaging final cell lines to meet strict quality criteria and collaborate with colleagues within GSK’s GMP facility to transition project cell lines into a manufacturing environment. Regulatory facing documentation is required to support these cell line transfers and CLD scientists are accountable for demonstrating scientific rigour in all aspects of their work and experimental recording.

The Cell Line Development team are seeking to maximise the impact of recent investments in state-of-the-art automation, imaging and data analysis by the recruitment of an exceptional Senior Scientist who will work within the core Project CLD team and facilitate the delivery of cell lines for the Biopharm portfolio.

The Senior Scientist role will report to the Project CLD Team Leader and be an integral member of the team working towards Biopharm portfolio delivery. This is a fast-paced, lab-based position and we are looking for an autonomous individual with a strong background in cell biology and experience in mammalian cell culture, with the aptitude to independently design and deliver work packages to advance the CLD platform. Our hope would be that the successful applicant could hit the ground running and make an immediate positive impact within the team. The ability to work collaboratively within a team - in addition to delivering on individual objectives, is fundamental to this role. Therefore, the successful applicant must demonstrate strong interpersonal and communication skills.

The role will include the application and optimisation of all aspects of cell line development; from Host cell and vector engineering, transfection optimisation, routine maintenance/analysis/passaging of suspension CHO cells, single cell cloning and imaging, cellular phenotype fingerprinting, clone selection through to cryopreservation of project critical cell banks.  There are numerous opportunities for personal development and training, particularly due to the cross-functional interactions that will be a key to success in this role and the applicants must be able to show a willingness to learn and develop themselves.

Role and Responsibilities

The successful applicant will be responsible for:

  • Supporting CLD project campaigns in the laboratory and communicating updates to key stakeholders as required.
  • Playing an active role in maintaining a high-performance lab environment, by managing their own time effectively, contributing to the daily upkeep of business-critical equipment and by supporting other team members to achieve shared objectives.
  • Supporting next-generation CLD work packages: From conceptual ideas through to experimental delivery and data analysis. Openly sharing findings and pro-actively seeking scientific input and critique.
  • Assisting in the authoring of detailed technical reports and process transfer documents required for cell bank transfer to GSK’s GMP facility.
  • Contributing to project and matrix teams as appropriate.
  • Seeking all opportunities to develop and maintain a strong Intellectual Property position.
  • Maintaining relationships with external professional, trade, and scientific organisations consistent with GSK business needs.

Basic Qualifications:

  • PhD in a relevant cell biology focused discipline or BSc/MSc in a relevant discipline with equivalent industrial experience
  • Demonstrable experience in Mammalian cell culture (preferably CHO)

Preferred Qualifications:

  • Hands on experience in Cell Line Development in an industrial setting and a good understanding of typical workloads, challenges and bottlenecks that may be encountered
  • Experience in any of the following would be a benefit
    • Liquid-handling automation and programming/ Flow cytometry/high-content imaging/genome engineering and sequencing analysis
  • Evidence of implementing innovative technical solutions in their research or work.
  • Hands on experience in standard molecular biology techniques.
  • Experience with data visualisation skills (Spotfire/JMP/Tableau)
  • Excellent planning, communication and interpersonal skills

About GSK:

We are a science-led global healthcare company that puts patients first. Our innovative medicines, vaccines and consumer health products enable millions of people across the world to do more, feel better and live longer. Join us as a scientist within R&D and you can look forward to a worthwhile and fulfilling career. Great emphasis is placed in on-the-job learning and development to help you to thrive in our open and inclusive environment. We also trust and respect our people and reward their performance. We look forward to hearing from you.

As a company driven by our values of Patient focus, Transparency, Respect and Integrity, we know inclusion and diversity are essential for us to be able to succeed. We want all our colleagues to thrive at GSK bringing their unique experiences, ensuring they feel good and to keep growing their careers.  As a candidate for a role, we want you to feel the same way.

As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

As you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it.  Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially.

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