Senior Scientist - Immunology, Open to flexibility
Senior Scientist - Immunology, Open to flexibility
Capitalising on outstanding recent scientific and clinical progress in the field, the Epigenetics Discovery Performance Unit (DPU) at GSK is a place where innovation is a mindset. Our teams of scientists including chemists, biologists, DMPK experts and physicians share a common sense of purpose to develop drugs that take disease into remission and to ultimately find cures for immunoinflammatory diseases and cancer.
The Epigenetics DPU at GSK is a pioneering research unit in which scientists enjoy the freedom to push back the boundaries of knowledge within a collegiate atmosphere where everyone shares a common goal to make life better for patients. The Epigenetics DPU has an exciting opportunity for a biologist to join the Immuno-Epigenetics team located in Stevenage (UK).
We are seeking a motivated, flexible, highly productive bench scientist to conduct experimental hands-on work in the area of immunology to support various epigenetic drug discovery programmes.
Your responsibilities will include:
- Development and implementation of cellular phenotypic and molecular assays for the evaluation of epigenetics drugs in the context of the immune response. This will include the use of multiple-parameter flow cytometric and other cell-based assay techniques.
- Execution of phenotypic screens to support Lead Optimisation programmes.
- Investigation of the mechanism of action of epigenetic inhibitors using gene expression techniques.
- Hands-on work in the area of chromatin molecular biology, including ChIP may be required.
- Representing the DPU in project teams and providing biological experimental leadership in a particular area of research.
You will also be given the opportunity to represent the DPU, therapeutic area and Company by attending relevant meetings and by authoring publications in peer-reviewed journals.
During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process.
If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process.
Closing date for applications: 18th April 2018
When applying for this role, please use the 'cover letter' of the on-line application to describe how you meet the competencies for this role, as outlined in the job requirements above.
The information that you have provided in your cover letter and CV will be used to assess your application.
Thank you for your interest in this opportunity.
- BSc and relevant experience in cellular and molecular biology
- Relevant experience in cellular immunology.
- Demonstrated practical laboratory experience gained from working in industrial or academic research environments.
- Significant expertise in cell culture techniques (isolation and culture of primary human cells) and in optimisation and execution of cell-based assays (phenotypic and mechanistic) to support pharmacological evaluation of compounds.
- Expertise in molecular biology techniques (RNA isolation, RT-PCR analysis)
- Hands-on experience in multi-parameter flow cytometric techniques for the study of cellular responses.
- Fluent spoken /written English.
- PhD in immunology, pharmacology or biology.
- Significant previous research experience working in pharma industry to support drug discovery programmes.
- Hands-on experimental experience in chromatin Biology techniques such as ChIP will be a plus.
- Experience in bioinformatic analysis of large data sets such as those from next generation sequencing experiments would be an advantage.
At GSK we are a science-led global healthcare company. We research and develop a broad range of innovative products in three primary areas of Pharmaceuticals, Vaccines and Consumer Healthcare. Our mission is inspiring and challenging - to help people do more, feel better and live longer.
We have a significant global presence with commercial operations in more than 150 countries, a network of 86 manufacturing sites in 36 countries and large R&D centres in the UK, USA, Spain, Belgium and China.
You may apply for this position online by selecting the Apply now button.
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