Translational Immunologist, Open to flexible working

Location
Stevenage, Hertfordshire
Salary
£Competitive
Posted
08 Nov 2021
Closes
29 Nov 2021
Ref
301588
Contract Type
Permanent

The Immunology Research Unit comprises a team of outstanding immunologists and drug discovery experts focused on the identification and validation of a next generation of immunology targets across the breadth of innate and adaptive immunity. Employing a disease-agnostic approach, a focus on basic immunological mechanisms and targets with strong human genetic validation plus the application of advanced technologies such as functional genomics and machine learning accelerates our understanding of the impact of these genes on human immunology and disease. The Immunology Research Unit is well positioned to exploit this exciting opportunity and continue to build and progress an outstanding portfolio of future transformational medicines.

Within this context, a scientist with in vitro and in vivo experience is sought to join the Experimental Quantitative Pharmacology (eQP) group based at Stevenage (UK). The eQP function is a diverse and dynamic group of scientists with expertise in both immunologically-based mechanistic and disease-aligned in vivo models, and in vitro and analytical skill sets. As an integral part of the Immunology Research Unit, this group plays a key role in the in vivo validation of new targets, and the evaluation and progression of candidate molecules into clinical studies to support the portfolio.

The integration of disciplines across the Research organisation is expected to support progression of high-quality candidate molecules by establishing translational biology, PKPD relationships and delivering robust preclinical data packages to support key decision milestones. To help deliver this, scientists in eQP will work closely with the DMPK and modelling groups in the design and conduct of preclinical efficacy and mechanistic translational in vivo models of inflammation and autoimmunity. This overall data package will underpin molecule selection and human dose predictions, forming the basis of experimental medicine studies and aiming to reduce attrition during late stage development.

Having technical in vitro and in vivo expertise in the field of immunology, the successful candidate will work with eQP scientists and in project matrix teams, to develop and implement translational strategies to support in vivo target validation and progression of candidate molecules through preclinical research.

Your Responsibilities:

In this role, you will be responsible for initiating and directing the development and implementation of translational animal model strategies aligned to immunological targets and mechanisms that present new therapeutic opportunities for multiple disease indications.

Your demonstrated expertise as a lab-based immunologist, together with your ability to independently interpret and report translatable animal model efficacy data, will enable the team to generate decision making data to support the Immunology portfolio.

As a member of the eQP group, you will be expected to interact productively with other biology groups within the Research Unit and with support functions across GSK. To effectively enable these interactions, you will be a strong communicator while also demonstrating networking skills and be accustomed to peer review and working in a matrix environment.  You will be able to initiate and lead appropriate in vivo strategies and communicate your scientific ideas and rationale for experimental designs and use your scientific expertise to problem solve.

Your background will include scientific accomplishments in robust experimental design and analysis of translatable endpoints relating to immunological mechanisms, ideally with experience in drug discovery. You will also have a good understanding of the Home Office legislation, and the ability to balance science and welfare relating to animal study conduct.

Key Responsibilities:

  • Hands on and in-depth application of techniques to interrogate immunological mechanisms (design and utilisation of multi-parameter flow cytometry panels for investigation of immune cell populations, gene and protein analysis) in animal model efficacy and PKPD studies
  • Identification of translatable endpoints and biomarkers from animal models, and developing robust assays for their assessment
  • Independent application of experimental design and oversight of animal studies and engaging with key business partners to ensure robust study design
  • Data analysis, integration and interpretation for timely communication of results to eQP leaders and project teams
  • Accurate data capture in the electronic Lab Note Book system and report writing in line with data integrity standards
  • Independent delivery of robust preclinical biology data packages to support key milestone decisions for discovery projects in the Immunology Research Unit portfolio
  • Working independently and across functions in a flexible team environment
  • Initiating and providing input to and implementation of novel ideas and innovative approaches, including new technologies and techniques
  • Ensuring compliance with GSK Values and Policies

Basic Qualifications

We are looking for professionals with these required skills to achieve our goals:

  • BSc or MSc in immunology, translational science or pharmacology
  • Deep understanding of mechanisms involved in the immune response
  • Strong and proven technical expertise and hands-on experience of flow cytometry, including multi-parameter panel design, data analysis and interpretation
  • Demonstrable experience of working with animal model systems and endpoints to increase understanding of immunological disease mechanisms/targets and their translation to man
  • Demonstrated application of robust in vivo experimental design and study oversight
  • Ability to maintain high standards of compliance and data integrity
  • Proven ability to work across boundaries in a matrix team environment
  • Strong written and oral communication skills
  • Track record of novel assay development and optimisation

Preferred Qualifications

  • Drug discovery experience
  • Expertise in neuroinflammatory model systems
  • Experience of protein and gene analysis, including assay development, validation and data analysis
  • Home Office personal licence holder
  • Ability to train others in flow cytometry and other in vitro techniques
  • PhD in immunology or related field

Why GSK?

Our values and expectations are at the heart of everything we do and form an important part of our culture.

These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:

  • Operating at pace and agile decision-making – using evidence and applying judgement to balance pace, rigour and risk.
  • Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
  • Continuously looking for opportunities to learn, build skills and share learning.
  • Sustaining energy and well-being.
  • Building strong relationships and collaboration, honest and open conversations.
  • Budgeting and cost-consciousness.

At GSK, we're a company with a special purpose, to help people do more feel better and live longer. Realising our purpose starts with us. When we feel at our best, we perform at our best.

When you set out on your adventure at GSK, we make a deal. You commit to living GSK's values and expectations and performing against our Innovation, Performance and Trust priorities. And in return, GSK commits to providing the right environment for you to thrive. Put simply, it’s about you being motivated to do your best work, in a place where you can be you, feel good and keep growing.

Together we build an environment where we can all thrive and focus on what matters most to each of us. It is only through the energy, dedication, drive and passion of all of us that we can be the very best for GSK, and importantly, for our patients and consumers.

As a company driven by our values of Patient focus, Transparency, Respect and Integrity, we know inclusion and diversity are essential for us to be able to succeed. We want all our colleagues to thrive at GSK bringing their unique experiences, ensuring they feel good and to keep growing their careers.  As a candidate for a role, we want you to feel the same way.

As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

As you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it.  Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially.

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