Investigator/Molecular Histologist (open to flexible working)
We are currently recruiting a brand new position within our Pathology team. This new role as a Molecular Histologist will provide advanced molecular histology expertise to the TMCP histology group. This will increase the effectiveness of support for current and future Discovery projects. To develop and supervise a small group of Molecular Histologists.
- Successfully develop multiplex immunohistochemistry/Immunofluorescence (IHC/IF)/in situ hybridization (ISH) and dual IHC/ISH protocols on automated slide based platforms, troubleshooting antibody clones and dilutions, antigen retrieval and signal amplification technologies
- Build molecular histology/pathology capability through training and supervising a histology team with the necessary molecular pathology capabilities to support the nature and complexity of current and future Discovery requests
- Introduce molecular histology techniques (Proteomics, QPCR and RT-PCR) alongside IHC & ISH in frozen and formalin fixed paraffin embedded human and animal tissues as part of antibody/ISH probe optimisation & validation
- Work collaboratively with Discovery pathologists to identify project needs and develop tissue based experiments to address project questions by agreed timelines
- Play a significant role within the GSK histology network identifying, researching and recommending the molecular technologies GSK needs to have in place to support the new research strategy
- Independently determine optimal assay conditions to assess biotherapeutics for Tissue Cross Reactivity (TCR) studies. Transfer optimised method to contract research organisations for application to GLP studies on projects
- Digital imaging, development and application of image analysis (IA) algorithms using commercially available IA platforms for selected studies eg: HALO, Aperio, Definiens and Visiopharm
- Maintain a high level of documentation for all experimental work to ensure data integrity (DI) expectations are met.
The position is available in Stevenage, Hertfordshire, UK
During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process.
If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process.
When applying for this role, please use the 'cover letter' of the on-line application to describe how you meet the competencies for this role, as outlined in the job requirements above.The information that you have provided in your cover letter and CV will be used to assess your application.
Thank you for your interest in this opportunity.
Closing date for applications: 28th Sept 2018
- BSc or above in a relevant area such as molecular biology
- Experience in molecular histology techniques (Proteomics, QPCR and RT-PCR) alongside IHC & ISH in frozen and formalin fixed paraffin embedded human and animal tissues as part of antibody/ISH probe optimisation & validation
- Extensive experience of histology and sample preparation.
- Management or leadership experience would be an advantage
- Experience of image analysis across multiple signals.
GlaxoSmithKline is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a structure for delivery and strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.
You may apply for this position online by selecting the Apply now button.
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