Investigator/Senior Scientist, Cell Line Development, Cell & Gene Therapy

Location
Stevenage, Hertfordshire
Salary
£Competitive
Posted
02 Sep 2018
Closes
21 Sep 2018
Ref
WD181017
Contract Type
Permanent

GSK is seeking a lab based Senior Scientist/Investigator (dependant on experience) to join our Cell Line Development (CLD) group located at our site in Stevenage (UK).

The CLD group is responsible for developing production cell lines for viral vectors using our Stable Cell Line Technology. The successful candidate will have a unique opportunity to develop novel technologies and approaches to establish an industrial CLD platform to progress our pipeline toward clinical and commercial development within GSK's Cell & Gene Therapy (CGT) Platform Development Group which is responsible for delivering the Chemistry, Manufacturing and Controls (CMC) aspects of the projects from early phase to launch and the development of innovative improvements to the design and manufacture of cell and gene therapy medicines.

A highly motivated and independent individual is sought to work within this team. The successful candidate will be expected to:

  • Design and execute experiments independently and troubleshoot technical issues
  • Be a key contributor and work collaboratively with other members of CLD campaign teams to deliver commercially viable stable viral vector producer cell lines for specific projects
  • Develop and establish innovative approaches to improve GSK's CLD process for the generation of mammalian cell lines for use in production of clinical lentiviral and AAV vectors for gene therapy
  • Work effectively in a matrix team, working closely with colleagues in molecular biology, vector process, analytical development and cell banking (external contract laboratories) as well as interact with quality and regulatory experts to support global regulatory filings.

The successful candidate will have track record in industrial cell line generation and a strong background in mammalian tissue culture and associated analytical techniques, preferably in the pharmaceutical industry, and be comfortable operating in a multidisciplinary, collaborative and fast-paced environment.

Relevant experience includes transfection, antibiotic selection, single cell cloning, qPCR, ddPCR, and flow cytometry. An interest in and/or experience of working with viral vectors, automation and liquid handling and would be an advantage.

The successful candidate will report to the Manager of the Cell Line Development team. The role will be based at Stevenage in the UK.

GlaxoSmithKline (GSK) is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery for strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer. The progression and expansion of our product portfolio together with the maturation of the emerging gene therapy technologies requires GSK to increase our investment in this space and establish an 'end-to-end' leading platform.

During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process.

If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process.

When applying for this role, please use the 'cover letter' of the on-line application to describe how you meet the competencies for this role, as outlined in the job requirements above.The information that you have provided in your cover letter and CV will be used to assess your application.

Thank you for your interest in this opportunity.

Closing date for applications: 21st Sept 2018

*LI-GSK

Why You?
Basic qualifications:

  • PhD or several years of laboratory experience in cell sciences and manufacturing cell line development
  • Experience of mammalian tissue culture techniques
  • Experience of methods for generation of stably transfected mammalian cell lines
  • PhD or equivalent number of years of laboratory experience in cell sciences and manufacturing cell line development
  • Experience of mammalian tissue culture techniques
  • Experience of methods for generation of stably transfected mammalian cell lines.

Preferred qualifications:

  • Experience of viral vectors
  • Experience of conducting cell-based assays and data analysis
  • Experience of using automated liquid handling systems
  • Experience of programming process instructions for automated liquid handling systems.

Why GSK?:
GlaxoSmithKline (GSK) is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery for strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer. The progression and expansion of our product portfolio together with the maturation of the emerging gene therapy technologies requires GSK to increase our investment in this space and establish an 'end-to-end' leading platform.

Contact information:
You may apply for this position online by selecting the Apply now button.

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