Scientific Investigator - Open to flexible working
An exciting opportunity has arisen for a highly motivated and skilled biologist to join our Oncology Discovery Technologies team within the Genomic Sciences department at our UK Research Site as a Scientific Investigator. With a particular focus on Oncology novel target discovery, the mission of our group is to unlock the genetic clues underlying human disease, thereby delivering new and better medicines for individuals with serious and greatest unmet medical need. To this end, we leverage the power of CRISPR and other gene editing technologies in high-throughput screening approaches for the discovery and validation of novel disease targets, understanding mechanisms of drug action & resistance and identifying potential combination therapies. The successful candidate will be part of a team exploring and applying advanced gene editing technologies for target discovery, disease model validation and biomarker discovery.
Exceptional scientists with extensive CRISPR gene editing experience, broad experience in molecular and cellular biology including experience in oncology and complex cellular models are highly encouraged to apply. The ideal candidate will also share our team values which include integrity, collaboration, diversity of thinking and respect.
In this role you will
- Your primary focus will be in the laboratory, with a deep desire to be involved in driving drug discovery projects. You will be expected to perform laboratory experiments, data analysis, record keeping and reporting of results to agreed timelines, and give presentations at both internal and external meetings.
- You will demonstrate the ability to work effectively in multidisciplinary teams and will display excellent interpersonal and communication skills, interacting with scientists and external collaborators at all levels.
- For this position, you will be expected to maintain knowledge of current scientific literature relevant to the role e.g. latest CRISPR developments, cancer biology.
- A proactive attitude, excellent organizational skills and good record keeping are essential.
- Ensure compliance with all GSK R&D data integrity practices, ethics codes, standards and training, and safety training and practices.
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When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.
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Qualifications & Skills:
We are looking for professionals with these required skills to achieve our goals:
- PhD or equivalent experience in genomics, molecular and cellular biology or a related discipline
- broad experience with genome editing or functional genomics screening in mammalian systems
- background in oncology research & cancer biology
- extensive cell culture experience using in vitro cancer cell models (experience in complex 3D models e.g. organoids would be a plus)
- sound knowledge of molecular biology
- strong communication skills; ability to generate scientific reports and present data to senior stakeholders
- proven ability to work independently and as part of a multidisciplinary team
Preferred Qualifications & Skills:
If you have the following characteristics, it would be a plus:
- fluency across a multitude of scientific techniques including genetic, proteomic, imaging, and/or other 'omics technologies
- experience in using software applications in complex data analysis and interpretation
- comfortable improving current or defining new ways of working
- strong track record of delivery
- proactively identifies and resolves issues and hurdles
At GSK, we have delivered unprecedented change over the past four years - to improve R&D productivity and performance, transform commercial execution and to , strengthen our leadership and reshape our organisation. Now, we’re getting ready to deliver the most significant change to our company in over 20 years. We’re on track to separate and create two ambitious new companies in 2022: A new GSK with a leading portfolio of vaccines, specialty and general medicines, and R&D based on the science of the immune system and genetics; and a new world-leading consumer healthcare company built on brands and innovation and delivering better everyday health.
With new ambition comes new purpose. GSK will unite science, talent, and technology to get ahead of disease together. We’ll be a company where outstanding people thrive, delivering strong, sustainable returns to our shareholders and with the power to improve the health of more than 2.5 billion people over the next 10 years.
All of this depends on our people and our culture. A culture that is ambitious for patients – so we deliver what matters better and faster; where we are all accountable for our impact and supported to succeed; and where we do the right thing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.
R&D At GSK, we want to find new medicines and vaccines in ways that are faster, more effective and more predictable.
We start with what matters most, the science. Our approach to R&D focuses on science related to the immune system, the use of human genetics, and advanced technologies. Our pipeline currently comprises of more than 60 vaccines and medicines across four core therapeutic areas including oncology, infectious diseases, immunology / respiratory and HIV. We have pivotal study starts in 2021 for our RSV vaccine in older adults, COVID-19 assets, long-acting anti-IL-5 antagonist, daprodustat, and dostarlimab. In oncology, momentum is building with 15 potential medicines in trials, including nine immuno-oncology and three cell therapies.
We give our scientists the freedom to own the process. Our scientists often use genetic data to help us understand the root cause of disease. We steer the research where the data shows we can do most good. If a project doesn’t pan out, we take what we’ve learned and apply it elsewhere.
Technology can help us find patterns in genetic data better and faster. We’re using machine learning to unlock the potential of complex genetic data with new levels of speed, precision, and scale. And we’re one of the first biopharmaceutical companies to have created an in-house AI lab dedicated to drug development.
Even with the knowledge, tools, and resources within GSK, there’s always a benefit to new perspectives. That's why we're increasingly partnering with and hiring outstanding people from cutting edge fields like tech, data-science and academia. In 2018, GSK formed an exclusive, highly innovative collaboration with 23andMe, the world's leading consumer genetics and research company. Other partners include: the Altius Institute; the UK Biobank, which is generating anonymized genetic sequence data from 500,000 volunteers; and the Open Targets Consortium, the mindset and approach of smaller, more agile startups.
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