Biotransformation Scientific Leader, Open to flexibility

Stevenage, Hertfordshire
16 Oct 2018
12 Nov 2018
Contract Type

Biotransformation Scientific Leader, Open to flexibility

GSK is a science-led global healthcare company with R&D playing a fundamental role in helping GSK to achieve its mission - enabling people to do more, feel better and live longer. The Analytical Sciences and Development (ASD) department, part of Platform Technology & Sciences (PTS), undertakes critical expert work in supporting the drug development process as well as existing products, to deliver new medicines to patients by accelerating access to novel medicines, preventions and cures.

The Global Spectroscopy (GS) group, part of ASD, is responsible for all the spectroscopic activities that take a drug candidate from earliest development into manufacturing. As part of this, the spectroscopy group solves structural chemistry problems for biologists, chemists and analysts by making intelligent and coordinated use of MS, NMR, vibrational spectroscopy and allied hyphenated techniques. The group uses state-of-the-art equipment in a modern laboratory and works closely with scientists around the world in GSK.

We currently have a vacancy for a biotransformation expert who is looking for an opportunity to lead a team of spectroscopists in delivering biotransformation information to drug discovery and development programs. In this exciting role, you will have responsibility and accountability for the delivery of high quality metabolism data for molecules across the GSK portfolio, allowing key decisions to be made relating to human safety.

The principle duties of the role are to:

  • Coordinate, plan, design, execute and report bespoke biotransformation studies to further the course of Discovery and Development projects and programs by enabling key decisions to be made impacting human safety
  • Integrate MS and NMR data in collaboration with NMR experts
  • Contextualise and extrapolate drug metabolism findings and discuss data with program/project team members
  • Develop a deep understanding of all areas of Drug Metabolism and Pharmacokinetics through integration with Project Experts
  • Explore and implement innovative mass spectrometry methodology and procedures
  • Supervise, train, develop and motivate team members
  • Act as mentor, coach and consultant in metabolite identification
  • Comply with the requirements of Quality, Safety and GSK policies and procedures and ensure that GSK intellectual property is protected

Application Details

During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process.

If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process.

Closing date: 12th November 2018

Thank you for your interest in this opportunity.


Why You?

Basic qualifications:

  • Analytical Chemistry, preferably in a mass spectrometry related discipline
  • Proven track record of metabolite characterisation and quantification using mass spectrometry
  • Proven track record of the development of bespoke LC-MS methodologies for structure elucidation using state-of-the-art high resolution instrumentation
  • Demonstrate a high level of problem solving capability by identifying and troubleshooting unexpected results or findings
  • Track record of innovation in the field of mass spectrometry supported by publications and presentations at international conferences
  • Proven track record of generating high quality data and reports
  • Knowledge of spectroscopic techniques other than mass spectrometry, for example, NMR would be an advantage

Preferred qualifications:

  • Proven track record of all aspects of the biotransformation discipline and an ability to integrate this knowledge into drug discovery and development programs
  • Experience in Drug Metabolism and Pharmacokinetic project leadership
  • Matrix or line leadership experience

Why GSK?:

At GSK, our mission is to improve the quality of human life by enabling people to do more, feel better and live longer. Our three world-leading businesses research and deliver innovative medicines, vaccines and consumer healthcare products. We need a talented and motivated workforce to deliver against our strategy. To achieve this, we strive to attract the best people and to create an environment that empowers and inspires.

Contact information:
You may apply for this position online by selecting the Apply now button.

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