Investigator E3-ligase biology – Protein Degradation - open to flexibility
The Protein Degradation group, based in Stevenage is working on a completely new approach to modulating disease pharmacology in cells. Instead of simply inhibiting the function of a drug target, we are able to remove the protein from cells completely. We do this by making use of the Ubiquitin Proteasome System) and redirecting it to remove specific proteins. We use bifunctional molecules known as Proteolysis Targeting Chimeras (Protacs) which recruit a cellular ubiquitin ligase to the target protein allowing tagging of the protein with ubiquitin chains for subsequent destruction by the proteasome.
We're currently looking for talented scientists to join our innovative Protein Degradation team for the development of novel E3 ligase binders for PROTACs.
Key Responsibilities include, but are not limited to:
• Supporting hit-to lead and lead-op development for E3-ligases and test PROTACs in cellular assays.
• Investigating ligase expression by utilising bioinformatic tools and experimental exploration.
• Providing expertise in the area of ubiquitin signaling and E3-ligase biology; independently and creatively designing, developing and executing experimental plans to predict, assess and mitigate PROTAC related safety risks.
• Collaboration with stakeholders across GSK, academia and other business partners to maintain an awareness of scientific developments in this field that will influence drug discovery and contribute to the continuous improvement by identifying opportunities for scientific leadership.
CLOSING DATE for applications: Friday 3rd May (COB)
Please take a copy of the Job Description, as this will not be available post closure of the advert.
When applying for this role, please use the 'cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.
During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process. If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process.
Why You?Basic qualifications:
• PhD in biology, biochemistry or a related discipline
• Experience and track record in protein degradation and the characterisation of E3 ligases.
• Ability to work independently and collaborate in order to achieve objectives
• Understanding of techniques and technologies relevant to in-vitro systems, including cell culture and cell-based assay systems utilising cell lines and primary cells (examples could include high content screening, -omics technologies, advanced cell systems and gene editing).
• To be an effective member of Protein Degradation team, contributing novel ideas and using judgment and knowledge where appropriate to influence the work of the project.
• Understanding of the drug discovery process from experience in the biotech/pharmaceutical industry. Experience with design and execution of in-vitro to determine the effects of E3-ligases on biological systems, including data analysis.
GlaxoSmithKline is a science-led global healthcare company that researches and develops a broad range of innovative medicines and brands. We discover, make and market life-enhancing products that are used by millions of people around the world, helping them to do more, feel better and live longer. We have 3 primary areas of business in pharmaceuticals, vaccines and consumer healthcare. We have offices in more than 115 countries, major research centers in the UK, USA, Spain, Belgium and China and an extensive manufacturing network with 87 sites globally. Our three strategic priorities are to grow a diversified global business, deliver products of value, and to simplify our operating model.
You may apply for this position online by selecting the Apply now button.
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